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Speciation by HPLC-ICP-MS (Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry) is an advanced analytical technique that combines the separation capabilities of High Performance Liquid Chromatography (HPLC) with the sensitive detection power of inductively coupled plasma mass spectrometry (ICP-MS). This method is widely used for the analysis of different chemical species (e.g., ions, molecules, complexes) of elements in a sample.