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GAS CHROMATOGRAPHY-FTIR (GC-FTIR | GC-MS-FTIR)
GC-FTIR (Gas Chromatography-Fourier Transform Infrared Spectroscopy) combines the separation power of gas chromatography with the structural identification capabilities of infrared spectroscopy, allowing for the identification of compounds in a mixture based on their retention time and IR absorption bands
What is GC-FTIR:
By coupling Gas Chromatograph (GC) and Fourier Transform Infrared Spectroscopy (FTIR), the separated compounds from GC are then analyzed by FTIR, allowing for the identification of the individual compounds based on their IR spectra
Strengths
- GC-FTIR is used in various fields, including:
- Identification of Isomers: GC-FTIR can distinguish between isomers (compounds with the same molecular formula but different structures) based on their unique IR spectra.
- Forensic Science: Analyzing evidence samples for the presence of specific compounds.
- Novel Psychoactive Substances
- Controlled Substances
- Chemical Weapons
- Pheromones
- Environmental Analysis: Identifying pollutants in air and water.
- Chemical Analysis: Identifying and characterizing organic compounds.
- Food Science: Analyzing flavors and fragrances in food products.
- Flavors and Fragrances
- Food and beverages
- Diastereomers
- Pharmaceutical Industry: Analyzing drug compounds and their metabolites.
- Rapid Analysis: GC-FTIR provides a relatively fast and efficient method for identifying compounds.
- Versatile: Applicable to a wide range of compounds, from volatile organic compounds to non-volatile compounds.
- GC-FTIR-MS: Another technique that combines GC with FTIR and Mass Spectrometry (MS) for simultaneous GC-FTIR and GC-MS data from a single injection.
Interface
The interface in GC-FTIR is a key part of the combined system. At present, there are two types of commercial interfaces: light pipe interface and frozen trap interface. The frozen capture interface has the advantages of high signal-to-noise ratio and low detection limit, but it is expensive and cumbersome to operate. The light pipe interface has the advantages of real-time recording, relatively cheap, and easy to operate, and is still widely used.
- Fourier transform infrared spectrometer: In GC-FTIR, single optical path FTIR is generally used.
- Computer data system: Control online operation and collect and process data.
Data Information of GC- FTIR
- Chromatographic retention value
The chromatographic retention value can be used as a qualitative auxiliary basis. The chromatographic retention value is very important for compounds with different numbers of repeating units in the molecular structure such as homologs. Because these compounds have similar infrared spectral characteristics but different chromatographic retention values.
- Chromatogram
The chromatogram obtained by GC-FTIR is called the reconstructed chromatogram, which is the result of computer processing the interferogram recorded by the infrared detector.
- Infrared spectra
The infrared spectrum characterizes the absorption frequency and intensity of each group in the compound molecule. Infrared spectroscopy can be used to identify the molecular structure of the compound.
- GC-FTIR library search
Comparing the gaseous infrared spectrum obtained by GC-FTIR with the gaseous infrared standard spectrum stored in the computer can realize the confirmation of unknown components.
